Colorectal cancer is the third most common cancer in the United States. Although screening has led to a decrease in incidence ...

A research team has conducted a study exploring the role of the mannose pathway in regulating cell fate decisions in low glucose environments. Their work may hold potential for novel therapeutic ...

CD25 expression has long been recognized as an adverse prognostic marker in acute leukemias including acute myeloid leukemia ...

Pro-inflammatory M1 macrophages involved in immune responses accelerate the progression of melanoma through the extracellular vesicles they secrete, a recent study from the University of Eastern ...

Druggable phosphatases in cancer and immune cells, with examples of their corresponding drugs. Structures of allosteric inhibitors targeting PP2A, PRL3, DUSP1/6, and SHP2 in cancer cells (left).

The researchers used lipid nanoparticles (LNPs) to deliver cyclic GMP-AMP (cGAMP) synthase (cGAS) mRNA to cancer cells. This results in production of the endogenous stimulator of interferon genes ...

Colorectal tumors that underwent somatic next-generation sequencing (NGS) for 154-168 genes in an in-house laboratory between 2015 and 2022 were retrospectively identified. Microsatellite instability ...

Cancer research continues to evolve as scientists strive to unravel the complexities of tumor biology, molecular signaling, and metabolic adaptations.

Researchers from The University of Osaka find that chronic liver congestion is linked to severe liver diseases through a specific signaling pathway in liver sinusoidal endothelial cells - key cells ...

JCO Precision Oncology Conversations features discussions with leading authors of JCO Precision Oncology articles, hosted by Dr. Abdul Rafeh Naqash. Join our experts in engaging conversations as they ...

QIMR Berghofer-led research in collaboration with Australian oncology company Kazia Therapeutics has found that combining the drug candidate paxalisib with immunotherapy triggered a molecular ...