Before going over their fundamental differences, let's address the main question. Yes, Python can do virtually everything Excel can. But it’s not an apples-to-apples comparison.

Microsoft today announced the public preview of Python in Excel, which will allow advanced spreadsheet users to combine scripts in the popular Python language and their usual Excel formulas in the ...

The new Anaconda Python Distribution in Excel, which is currently in beta, will bring Python data analysis and data science capabilities to the popular spreadsheet program from Microsoft. The ...

Until now, users had to run Python code on Microsoft Azure’s cloud servers. To provide Python in Excel locally, Anaconda used Microsoft’s existing Excel plugin capabilities combined with their own ...