PRP vs. Cortisone Shots — Which Works Better for Knee Pain? A new randomized clinical trial found that corticosteroid injections provided faster short-term pain relief than platelet-rich plasma (PRP) for patients with knee osteoarthritis. 💡 Key Takeaways from the Study: At six weeks, patients who received corticosteroid injections reported significantly greater pain relief. PRP did NOT outperform cortisone injections in early recovery. By 3 months, both treatments showed similar levels of pain